Rare side effects (may affect up to 1 in 1,000 people): Inflammation of the lung (bronchitis), activation or worsening of systemic lupus erythematosus (a disease where the body’s immune system attacks the body, which causes joint pain, skin rashes and fever); sore throat, inflamed sinuses, feeling sad (depression), difficulty falling asleep (insomnia), impaired vision, difficulty breathing, abdominal pain, constipation, bloating (dyspepsia), feeling sick, inflammation of the stomach (gastritis), abnormal liver function (Japanese patients are more likely to experience these side effect), rapid swelling of the skin and mucosa which can al ...[+++]so lead to death

Rare side effects (may affect up to 1 in 1,000 people): Inflammation of the lung (bronchitis), activation or worsening of systemic lupus erythematosus (a disease where the body’s immune system attacks the body, which causes joint pain, skin rashes and fever); sore throat, inflamed sinuses, feeling sad (depression), difficulty falling asleep (insomnia), impaired vision, difficulty breathing, abdominal pain, constipation, bloating (dyspepsia), feeling sick, inflammation of the stomach (gastritis), abnormal liver function (Japanese patients are more likely to experience these side effect), rapid swelling of the skin and mucosa which can al ...[+++]so lead to death (angioedema also with fatal outcome), redness of the skin (erythema), allergic reactions such as itching or rash, increased sweating, hives (urticaria), joint pain (arthralgia) and pain in extremities, muscle cramps, flu-like-illness, pain, increased levels of uric acid, low levels of sodium, increased levels of creatinine, hepatic enzymes or creatine phosphokinase in the blood.

Uncommon (may affect up to 1 in 100 people) fast heart beat spinning sensation vision disorder stomach discomfort chest pain increase of urea nitrogen, creatinine and uric acid in the blood high level of calcium, fat or sodium in the blood decrease of potassium in the blood breath odour diarrhoea dry mouth nausea vomiting abdominal pain weight increase loss of appetite disturbed sense of taste back pain joint swelling muscle cramps/weakness/pain pain in extremity inability to either stand or walk in a normal manner weakness abnormal coordination dizziness on standing up or after exercising lack of energy sleep disturbances tingling or nu ...[+++]mbness neuropathy sleepiness

loss of appetite disturbed sense of taste back pain joint swelling muscle cramps/weakness/pain pain in extremity inability to either stand or walk in a normal manner weakness abnormal coordination dizziness on standing up or after exercising lack of energy sleep disturbances tingling or numbness neuropathy sleepiness sudden, temporary loss of consciousness low blood pressure on standing up impotence cough breathlessness throat irritation excessive sweating itching swelling, reddening and pain along a vein skin reddening trembling

- cough, chest pain or tightness, hoarseness, sore or tight throat, sticky throat secretions, runny nose

Uncommon side effects (may affect up to 1 in 100 people): Urinary tract infections,upper respiratory tract infections (e.g. sore throat, inflamed sinuses, common cold), deficiency in red blood cells (anaemia), high potassium levels, difficulty falling asleep, feeling sad (depression), fainting (syncope), feeling of spinning (vertigo), slow heart rate (bradycardia), low blood pressure (hypotension) in users treated for high blood pressure, dizziness on standing up (orthostatic hypotension), shortness of breath, cough, abdominal pain, diarrhoea, discomfort in the abdomen, bloating, vomiting, itching, increased sweating, drug rash, back pai ...[+++]n, muscle cramps, muscle pain (myalgia), kidney impairment including acute kidney failure, pain in the chest, feeling of weakness, and increased level of creatinine in the blood.