An amendment to the Part IV of the Annex to Directive 2001/83/EC adopted on 14 September 2009 adapted some of the requirements in terms of the content of marketing authorisation applications for ATMPs.[5] In addition, a revised Guideline on good manufacturing practice containing specific adaptions for ATMPs applies since 31 January 2013.[6] However, the adoption of specific requirements regarding good clinical practice and traceability is still pending as additional experience was deemed necessary to better understand the type of adaptations required.[7]

As a first response, on 27 June 2012 the Commission adopted a Communication[1] (the "June Communication") which outlined how tax compliance can be improved and fraud and evasion reduced, through a better use of existing instruments and the adoption of pending Commission proposals.

(d)there are outstanding methodological issues likely to have a material effect on the debt or deficit statistics which have not been resolved between the Member State and the Commission (Eurostat) arising from the rounds for clarification or the previous dialogue visits, resulting in reservations from the Commission (Eurostat) in two subsequent EDP notifications.

Underlines that the resolution of the Israeli-Palestinian conflict is crucial to securing peace and stability in the Middle East; reminds the parties of the commitments which they made in Annapolis to holding negotiations in good faith with a view to concluding a peace treaty by the end of 2008, resolving all outstanding issues; stresses again the importance of the Arab Peace Initiative and urges the EU and the United States to ensure the constructive involvement of Arab partners; reiterates its call on Israel to freeze all settlement activities, including natural growth, and to dismantle outposts erected since March 2001; reiterates ...[+++] its deep concern at the humanitarian and political crisis in the Gaza Strip and its further possible grave consequences; calls for an immediate end to the firing of rockets by Palestinian militias from the Gaza Strip into Israeli territory; fully supports the efforts by Egypt to bring about a cessation of violence and a solution that will allow for the reopening of all crossings;

(c) all allocated slots, and outstanding slot requests, listed individually in chronological order, by air carriers, for all air carriers,

This is extremely worrying, particularly as the number of requests outstanding now exceeds the number of requests made each quarter.