Ear and labyrinth disorders Uncommon: Vertigo, tinnitus, hearing loss Cardiac disorders Uncommon: Palpitations, tachycardia, cardiac failure congestive 3 , pulmonary oedema Rare: Arrhythmia, atrial fibrillation, cardiac arrest, myocardial infarction, angina pectoris, pericardial effusion Vascular disorders 4 Common: Flushing, haemorrhage Uncommon: Hypertension, haematoma, subdural haematoma, peripheral coldness, hypotension, Raynaud’s phenomenon Respiratory, thoracic and mediastinal disorders Common: Dyspnoea, epistaxis, cough Uncommon: Pleural effusion 5 , pharyngolaryngeal pain, pharyngitis Rare: Pleuritic pain, pulmonary fibrosis, pul ...[+++]monary hypertension, pulmonary haemorrhage Gastrointestinal disorders Very common: Nausea, diarrhoea, vomiting, dyspepsia, abdominal pain 6 Common: Flatulence, abdominal distension, gastro-oesophageal reflux, constipation, dry mouth, gastritis Uncommon: Stomatitis, mouth ulceration, gastrointestinal haemorrhage 7 , eructation, melaena, oesophagitis, ascites, gastric ulcer, haematemesis, cheilitis, dysphagia, pancreatitis Rare: Colitis, ileus, inflammatory bowel disease Hepatobiliary disorders Common: Increased hepatic enzymes Uncommon: Hyperbilirubinaemia, hepatitis, jaundice Rare: Hepatic failure 8 , hepatic necrosis Skin and subcutaneous tissue disorders Very common: Periorbital oedema, dermatitis/eczema/rash Common: Pruritus, face oedema, dry skin, erythema, alopecia, night sweats, photosensitivity reaction Uncommon: Rash pustular, contusion, sweating increased, urticaria, ecchymosis, increased tendency to bruise, hypotrichosis, skin hypopigmentation, dermatitis exfoliative, onychoclasis, folliculitis, petechiae, psoriasis, purpura, skin hyperpigmentation, bullous eruptions Rare: Acute febrile neutrophilic dermatosis (Sweet’s syndrome), nail discolouration, angioneurotic oedema, rash vesicular, erythema multiforme, leucocytoclastic vasculitis, Stevens-Johnson syndrome, acute generalised exanthematous pustulosis (AGEP) Musculoskele ...

Cardiac disorders Uncommon: Palpitations, tachycardia, cardiac failure congestive 3 , pulmonary oedema Rare: Arrhythmia, atrial fibrillation, cardiac arrest, myocardial infarction, angina pectoris, pericardial effusion Vascular disorders 4 Common: Flushing, haemorrhage Uncommon: Hypertension, haematoma, subdural haematoma, peripheral coldness, hypotension, Raynaud’s phenomenon Respiratory, thoracic and mediastinal disorders Common: Dyspnoea, epistaxis, cough Uncommon: Pleural effusion 5 , pharyngolaryngeal pain, pharyngitis Rare: Pleuritic pain, pulmonary fibrosis, pulmonary hypertension, pulmonary haemorrhage Gastrointestinal disorders Very common: Nausea, diarrhoea, vomiting, dyspepsia, abdominal pain 6 Common: Flatulence, abdominal diste ...[+++]nsion, gastro-oesophageal reflux, constipation, dry mouth, gastritis Uncommon: Stomatitis, mouth ulceration, gastrointestinal haemorrhage 7 , eructation, melaena, oesophagitis, ascites, gastric ulcer, haematemesis, cheilitis, dysphagia, pancreatitis Rare: Colitis, ileus, inflammatory bowel disease Hepatobiliary disorders Common: Increased hepatic enzymes Uncommon: Hyperbilirubinaemia, hepatitis, jaundice Rare: Hepatic failure 8 , hepatic necrosis Skin and subcutaneous tissue disorders Very common: Periorbital oedema, dermatitis/eczema/rash Common: Pruritus, face oedema, dry skin, erythema, alopecia, night sweats, photosensitivity reaction Uncommon: Rash pustular, contusion, sweating increased, urticaria, ecchymosis, increased tendency to bruise, hypotrichosis, skin hypopigmentation, dermatitis exfoliative, onychoclasis, folliculitis, petechiae, psoriasis, purpura, skin hyperpigmentation, bullous eruptions Rare: Acute febrile neutrophilic dermatosis (Sweet’s syndrome), nail discolouration, angioneurotic oedema, rash vesicular, erythema multiforme, leucocytoclastic vasculitis, Stevens-Johnson syndrome, acute generalised exanthematous pustulosis (AGEP) Musculoskeletal and connective tissue disorders Very common: Muscle spasm and cram ...

Rare side effects (may affect up to 1 in 1,000 people): Inflammation of the lung (bronchitis), activation or worsening of systemic lupus erythematosus (a disease where the body’s immune system attacks the body, which causes joint pain, skin rashes and fever); sore throat, inflamed sinuses, feeling sad (depression), difficulty falling asleep (insomnia), impaired vision, difficulty breathing, abdominal pain, constipation, bloating (dyspepsia), feeling sick, inflammation of the stomach (gastritis), abnormal liver function (Japanese patients are more likely to experience these side effect), rapid swelling of the skin and mucosa which can also lead to death (angioedem ...[+++]a also with fatal outcome), redness of the skin (erythema), allergic reactions such as itching or rash, increased sweating, hives (urticaria), joint pain (arthralgia) and pain in extremities, muscle cramps, flu-like-illness, pain, increased levels of uric acid, low levels of sodium, increased levels of creatinine, hepatic enzymes or creatine phosphokinase in the blood.

Common: loss of appetite, dizziness, taste disturbance, tingling, pain or numbness of the hands, feet, legs or around the hip, difficulty sleeping, discharge from the eye with itching, redness and swelling (conjunctivitis), blurred vision, increased tear production, dry eye, nose bleeds, swelling in the abdomen, gas (flatulence), constipation, heartburn, nausea and stomach pain (sign of gastritis), dry mouth, itching, dry skin, unusual hair loss or thinning, night sweats, weakness, increased muscle tension, hypersensitivity (allergies), decreased skin sensitivity, increased sensitivity of the skin to sun (sign of photosensitivity), hot f ...[+++]lushes, chills, decreased weight, mouth ulceration, joint swelling, abnormal liver test results, cough, fever, and swelling of the eyelids or around the eye.

of purpura or Henoch- Schonlein purpura if caused by an allergy). Blurred vision, or any visual disturbance Any change in the amount or colour of your urine (red or brown) Any pain or difficulty experienced while urinating Swelling of the feet, lower legs; weight gain Swelling mainly of the face and throat (signs of angioedema) Vomiting or persistent indigestion, nausea, stomach pain or diarrhea Yellow discolouration of the skin or eyes (signs of liver failure), with or without itchy skin Malaise, fatigue, loss of appetite or « flu-like » symptoms Headaches, stiff neck, fever, nausea, vomiting (signs of aseptic meningitis) Mental confus ...[+++]ion, depression

Ophthalmic disorders: decreased or blurred vision, glaucoma (a condition in which the pressure of fluid in the eye is high), exophthalmus (protruding eyeballs).