Increased or decreased levels of potassium in the blood: irregular heartbeats, muscle weakness and generally feeling unwell Severe diarrhea Allergic Reaction: Including angioedema: Symptoms like rash, hives, swelling of the face, lips, tongue or throat, difficulty swallowing or breathing Electrolyte Imbalance: weakness, drowsiness, muscle pain or cramps, irregular heartbeat Kidney Disorder: change in frequency of urination, nausea, vomiting, swelling of extremities, fatigue Liver Disorder: yellowing of the skin or eyes, dark urine, abdominal pain, nausea, vomiting, loss of appetite Increased blood sugar: frequent urination, thirst, and h ...[+++]unger Toxic epidermal necrolysis severe skin peeling, resembling severe burn, can occur anywhere on the body.

Side effects may include: sleep disturbance, fatigue and tiredness especially with activity, headache, dry mouth, nausea and vomiting, diarrhea or constipation and abdominal pain, numbness, a tingling sensation in the extremities signs of paresthesia, increased sensitivity of the skin to sun, sweating, hair loss, increased weight, and lower back pain.

In addition, erythema, and bone pain were observed less frequently (< 10% and ≥ 5%) in the TASIGNA* 400 mg twice daily group whereas pain in the extremity was observed less frequently (< 10% and ≥ 5%) in the TASIGNA* 300 mg twice daily group.

Increased or decreased levels of potassium in the blood: irregular heartbeats, muscle weakness and generally feeling unwell Severe diarrhea Allergic Reaction: Including angioedema: Symptoms like rash, hives, swelling of the face, lips, tongue or throat, difficulty swallowing or breathing Electrolyte Imbalance: weakness, drowsiness, muscle pain or cramps, irregular heartbeat Kidney Disorder: change in frequency of urination, nausea, vomiting, swelling of extremities, fatigue Liver Disorder: yellowing of the skin or eyes, dark urine, abdominal pain, nausea, vomiting, loss of appetite Increased blood sugar: frequent urination, thirst, and h ...[+++]unger Toxic epidermal necrolysis severe skin peeling, resembling severe burn, can occur anywhere on the body.

n (%) n (%) Pyrexia 63 (55.3) 37 (32.7) Malaise 51 (44.7) 36 (31.9) Headache NOS 34 (29.8) 32 (28.3) Hypoaesthesia 28 (24.6) 22 (19.5) Arthralgia 24 (21.1) 18 (15.9) Dyspnoea NOS 21 (18.4) 15 (13.3) Epigastric pain 19 (16.7) 8 (7.1) Leukopenia NOS 17 (14.9) 16 (14.2) Myalgia 15 (13.2) 13 (11.5) Pruritus NOS 13 (11.4) 12 (10.6) Oedema lower limb 13 (11.4) 4 (3.5) Anaemia NOS 12 (10.5) 7 (6.2) Pain NOS 12 (10.5) 11 (9.7) Shows no. of subjects experiencing at least 1 AE in category in question

Myalgia 23. 2% 25.7% 16.3% Anorexia 22.4% 14.6% 23.1% Cough 21.7% 23.2% 14.3% Arthralgia 21.0% 23.6% 16.0% Oedema lower limb 20.9% 22.7% 18.5% Malignant neoplasm aggravated 19.9% 17.4% 19.6% Headache NOS 18.5% 26.8% 11.0% Dizziness (excl. vertigo) 17.5% 16.4% 12.7% Insomnia NEC 16.1% 20.0% 16.0% Weight decreased 15.9% 9.0% 13.4% Back pain 15.1% 19.1% 8.8% Paresthesia NEC 14.5% 15.3% 7.7% Depression NEC 14.2% 17.1% 10.8% Pain in limb 13.9% 15.1% 11.4%