Acquired absence of finger(s) [including thumb], unilateral

Acquired absence of finger(s), bilateral

Acquired absence of both upper limbs [any level]

Acquired absence of upper limb above wrist

Acquired absence of hand and wrist

Acquired absence of limb

Acquired absence of foot and ankle

Acquired absence of leg at or below knee

Acquired absence of both lower limbs [any level, except toes alone]

Acquired absence of leg above knee

At 100 and 250 mg/kg/day, there were slight increases in postimplantation loss and slight decreases in fetal body weights. At 250 mg/kg/day, fetal malformations included limb anomalies (flexed and/or rotated fore- and/or hindlimbs, unattached or absent digit) and associated skeletal malformations (not ossified metacarpal, misaligned phalanx and metacarpal, absent digit, not ossified phalanx, and short not ossified or bent tibia); moderate dilation of the lateral ventricle in the brain; abnormal placement of the right subclavian artery; absent intermediate lobe in the lungs; lowset kidney; al ...[+++]tered liver morphology; incompletely or not ossified pelvis; an increased average for supernumerary thoracic ribs and a reduced average for ossified tarsals.

Encephalopathy (at least one of the following progressive findings present for at least 2 months in the absence of a concurrent illness other than HIV infection that could explain the findings): a) failure to attain or loss of developmental milestones or loss of intellectual ability, verified by standard developmental scale or neuropsychological tests; b) impaired brain growth or acquired microcephaly demonstrated by head circumference measurements or brain atrophy demonstrated by computerized tomography or magnetic resonance imaging ...[+++] (serial imaging is required for children < 2 years of age); c) acquired symmetric motor deficit manifested by two or more of the following: paresis, pathologic reflexes, ataxia or gait disturbance

Absence of menstrual periods (amenorrhoea) has been observed in some female patients receiving AFINITOR* Loss of hearing

Absence of menstrual periods (amenorrhoea) has been observed in some female patients receiving AFINITOR* Loss of hearing