Hormonal changes and tartar can combine to provoke an excess growth of gum tissue.

Oral manifestations are among the earliest and most important indicators of infection with HIV. Seven cardinal lesions, oral candidiasis, hairy leukoplakia, Kaposi sarcoma, linear gingival erythema, necrotizing ulcerative gingivitis, necrotizing ulcerative periodontitis and non-Hodgkin lymphoma, which are strongly associated with HIV infection, have been identified and internationally calibrated, and are seen in both developed and developing countries.

Haemorrhagic disorders Haemorrhagic disorders are listed under several system organ classes: Blood and lymphatic system disorders; nervous system disorders (intracranial haemorrhage); respiratory, thoracic and mediastinal disorders (epistaxis); gastrointestinal disorders (gingival bleeding, haemorrhoidal haemorrhage, rectal haemorrhage); renal and urinary disorders (haematuria); injury, poisoning and procedural complications (contusion) and vascular disorders (ecchymosis).

Very Common Rashes Common Urticaria, Hyperhidrosis, Dry Skin, Pruritus, Skin Hyperpigmentation, Eczema Uncommon Skin discolouration, Photosensitivity reaction Very Common Muscle Spasms, Bone Pain, Musculoskeletal and connective tissue pain and discomfort Common Joint swelling Common Haematuria^, Urinary retention, Urinary incontinence Uncommon Acquired Fanconi syndrome Common Erectile Dysfunction Very Common Fatigue, Oedema (including peripheral oedema), Pyrexia, Influenza like illness syndrome (including pyrexia, myalgia, musculoskeletal pain, headache and rigors) Common Chest Pain, Lethargy Common Contusion^

Mucocutaneous bleeding (eg, gingival bleeding)