That will generally mean that the security has to cover a sufficiently high percentage of the organiser's turnover in respect of packages, and may depend on factors such as the type of packages sold, including the mode of transport, the travel destination, and any legal restrictions or the organiser's commitments regarding the amounts of pre-payments he may accept and their timing before the start of the package.

The latter has emerged in virtually all healthcare-associated pathogens, and the majority of novel resistance factors first surface in healthcare facilities.

Increasing global trade and travel favours the spread of antimicrobial resistance between countries and continents. Therefore, antimicrobial resistance is a global public health concern.

This resistance is a natural biological phenomenon but is amplified by a variety of factors.

The factors of resistance to change are not confined to higher education institutes alone, but are also present in the administrative systems of the eligible countries.

Two additional criteria are being applied in the second phase (Council Decision of 14 December 1989: the cost of travel between Member States, and differences in cost of living. A minimum of ECU 200 000 is allocated to each Member State. To promote a more even distribution of exchanges within the Community, the Commission has also decided to make use of the 5% reserve fund provided for in the amended Decision. Thus 2% of the available resources will be allocated to Member States where demand for student mobility is particularly high (Ireland, Belgium, United Kingdom and France).